1. Preheat your oven to 375°F (190°C).
2. In a skillet over medium heat, sauté the diced onion and minced garlic until soft and aromatic. Let them cool slightly afterward.
3. In a large bowl, combine ground turkey, sautéed onions, garlic, breadcrumbs, eggs, milk or broth, Worcestershire sauce, 1/2 cup ketchup, salt, pepper, and Italian seasoning. Gently mix the ingredients with your hands until just combined, avoiding overmixing.
4. Shape the mixture into a loaf on a parchment-lined baking sheet or use a loaf pan as an alternative.
5. Prepare the glaze by combining 1/4 cup ketchup, brown sugar, and Dijon mustard in a small bowl. Spread half of the glaze over the surface of the meatloaf.
6. Place the meatloaf in the oven and bake for 40-50 minutes, ensuring the internal temperature reaches 160°F (71°C) using a thermometer.
7. In the final 10 minutes of baking, apply the remaining glaze to the meatloaf for a perfectly caramelized finish.
8. Once done, remove the meatloaf from the oven and let it rest for 5-10 minutes to allow the juices to redistribute.
9. Slice the meatloaf and serve it hot with your choice of sides, such as mashed potatoes or fresh salad.